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desvenlafaxine will improve the level or result of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Keep an eye on. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, four hundred mg) decrease the CYP2D6 substrate dose by nearly fifty%; no dosage adjustment desired with desvenlafaxine doses 7 consecutive times